ORAI2 antibody (C-Term)

Catalog No. ABIN6990742

This Rabbit Polyclonal antibody specifically detects ORAI2 in WB, ELISA, IF and ICC. It exhibits reactivity toward Human and Mouse.

Quick Overview for ORAI2 antibody (C-Term) (ABIN6990742)

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORAI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-ORAI2 Antibody

Binding Specificity: C-Term

Specificity: At least two isoforms of ORAI2 are known to exist, this antibody will detect both isoforms. ORAI antibody is predicted not to cross-react with ORAI1 or ORAI3.

Purification: ORAI2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ORAI2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human ORAI2. The immunogen is located within the last 50 amino acids of ORAI2.

Isotype: IgG

Application Details

Application Notes: ORAI2 antibody can be used for detection of ORAI2 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ORAI2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ORAI2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ORAI2

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Alternative Name: ORAI2

Background: ORAI2 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1.

Molecular Weight: Predicted: 19, 28 kDa

Observed: 29 kDa

Gene ID: 80228

UniProt: Q96SN7