CRLF2 antibody (AA 140-190)

Catalog No. ABIN6990749

The Rabbit Polyclonal anti-CRLF2 antibody has been validated for WB, ELISA, IHC (p) and IF. It is suitable to detect CRLF2 in samples from Human.

Quick Overview for CRLF2 antibody (AA 140-190) (ABIN6990749)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRLF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-CRLF2 Antibody

Binding Specificity: AA 140-190

Specificity: At least two isoforms of TSLP-R are known to exist, this antibody will recognize both isoforms.

Purification: TSLP Receptor Antibody is affinity chromatography purified via peptide column.

Immunogen: TSLP Receptor antibody was raised against a 19 amino acid synthetic peptide from near the center of human TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.

Isotype: IgG

Application Details

Application Notes: TSLP-R antibody can be used for detection of TSLP-R by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TSLP Receptor Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: TSLP Receptor

Background: TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells, co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.

Molecular Weight: Predicted: 28, 41 kDa

Observed: 53 kDa

Gene ID: 57914

NCBI Accession: NP_071431

UniProt: Q8CII9