CRLF2 antibody (AA 140-190)

Catalog No. ABIN6990750

This anti-CRLF2 antibody is a Rabbit Polyclonal antibody detecting CRLF2 in WB, ELISA and IF. Suitable for Mouse.

Quick Overview for CRLF2 antibody (AA 140-190) (ABIN6990750)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRLF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-CRLF2 Antibody

Binding Specificity: AA 140-190

Purification: TSLP Receptor Antibody is affinity chromatography purified via peptide column.

Immunogen: TSLP receptor antibody was raised against a 21 amino acid synthetic peptide from near the center of mouse TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.

Isotype: IgG

Application Details

Application Notes: TSLP receptor antibody can be used for detection of TSLP receptor by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TSLP Receptor Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: TSLP Receptor

Background: TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells, co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.

Gene ID: 57914

NCBI Accession: NP_057924

UniProt: Q8CII9