Stathmin 1 antibody (C-Term)

Catalog No. ABIN6990757

This Rabbit Polyclonal antibody specifically detects Stathmin 1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Stathmin 1 antibody (C-Term) (ABIN6990757)

Target: Stathmin 1 (STMN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stathmin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Stathmin 1 Antibody

Binding Specificity: C-Term

Purification: op18 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-op18 antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human op18. The immunogen is located within the last 50 amino acids of op18.

Isotype: IgG

Application Details

Application Notes: WB: 0.5-2 μ,g /mL, IHC: 2.5 μ,g /mL, IF: 20 μ,g /mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: op18 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: op18 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Stathmin 1

Target: Stathmin 1 (STMN1)

Alternative Name: op18

Background: Op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.

Molecular Weight: Predicted: 17kD

Observed: 17 kD kDa

Gene ID: 3925

UniProt: P16949

Pathways: MAPK Signaling, Microtubule Dynamics