FNBP1L antibody (N-Term)

Catalog No. ABIN6990816

This anti-FNBP1L antibody is a Rabbit Polyclonal antibody detecting FNBP1L in WB, ELISA, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for FNBP1L antibody (N-Term) (ABIN6990816)

Target: FNBP1L (Formin Binding Protein 1-Like (FNBP1L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNBP1L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-FNBP1L Antibody

Binding Specificity: AA 40-90, N-Term

Purification: TOCA-1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TOCA-1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human TOCA-1. The immunogen is located within amino acids 40 - 90 of TOCA-1.

Isotype: IgG

Application Details

Application Notes: TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TOCA-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TOCA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FNBP1L

Target: FNBP1L (Formin Binding Protein 1-Like (FNBP1L))

Alternative Name: TOCA-1

Background: TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells, its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

Gene ID: 54874

NCBI Accession: NP_001020119

UniProt: Q5T0N5