SP110 antibody (C-Term)

Catalog No. ABIN6990830

The Rabbit Polyclonal anti-SP110 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect SP110 in samples from Human, Mouse and Rat.

Quick Overview for SP110 antibody (C-Term) (ABIN6990830)

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP110 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SP110 Antibody

Binding Specificity: AA 470-520, C-Term

Purification: IPR1 Antibody is affinity chromatography purified via peptide column.

Immunogen: IPR1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1. The immunogen is located within amino acids 470 - 520 of IPR1.

Isotype: IgG

Application Details

Application Notes: Ipr1 antibody can be used for detection of Ipr1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IPR1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Alternative Name: IPR1

Background: IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

Gene ID: 3431

NCBI Accession: NP_004501

UniProt: Q9HB58