RIMS3 antibody (N-Term)

Catalog No. ABIN6990855

This anti-RIMS3 antibody is a Rabbit Polyclonal antibody detecting RIMS3 in WB, ELISA, IHC (p) and IF. Suitable for Human and Mouse.

Quick Overview for RIMS3 antibody (N-Term) (ABIN6990855)

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIMS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-RIMS3 Antibody

Binding Specificity: AA 60-110, N-Term

Specificity: This antibody is predicted to have no cross-reactivity to other Rim proteins.

Purification: Rim3 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rim3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Rim3. The immunogen is located within amino acids 60 - 110 of Rim3.

Isotype: IgG

Application Details

Application Notes: Rim3 antibody can be used for detection of Rim3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rim3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Rim3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RIMS3

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Alternative Name: Rim3

Background: Rim3 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.

Gene ID: 9783

NCBI Accession: NP_055562

UniProt: Q9UJD0

Pathways: Stem Cell Maintenance, Synaptic Vesicle Exocytosis