SLC35D1 antibody (C-Term)

Catalog No. ABIN6990906

The Rabbit Polyclonal anti-SLC35D1 antibody (ABIN6990906) specifically detects SLC35D1 in WB, ELISA and ICC. The antibody is reactive with Human samples.

Quick Overview for SLC35D1 antibody (C-Term) (ABIN6990906)

Target: SLC35D1 (Solute Carrier Family 35 (UDP-Glucuronic Acid/UDP-N-Acetylgalactosamine Dual Transporter), Member D1 (SLC35D1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC35D1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-SLC35D1 Antibody

Binding Specificity: C-Term

Specificity: This antibody is predicted to not cross-react with the highly homologous Slc35D2.

Purification: Slc35D1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Slc35D1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human Slc35D1. The immunogen is located within the last 50 amino acids of Slc35D1.

Isotype: IgG

Application Details

Application Notes: Slc35D1 antibody can be used for detection of Slc35D1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Slc35D1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Slc35D1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC35D1

Target: SLC35D1 (Solute Carrier Family 35 (UDP-Glucuronic Acid/UDP-N-Acetylgalactosamine Dual Transporter), Member D1 (SLC35D1))

Alternative Name: Slc35D1

Background: Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Gene ID: 23169

NCBI Accession: NP_055954

UniProt: Q9NTN3

Pathways: Glycosaminoglycan Metabolic Process