GDF6 antibody (C-Term)

Catalog No. ABIN6990939

This anti-GDF6 antibody is a Rabbit Polyclonal antibody detecting GDF6 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for GDF6 antibody (C-Term) (ABIN6990939)

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GDF6 Antibody

Binding Specificity: AA 320-370, C-Term

Purification: GDF6 Antibody is affinity chromatography purified via peptide column.

Immunogen: GDF6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human GDF6. The immunogen is located within amino acids 320 - 370 of GDF6.

Isotype: IgG

Application Details

Application Notes: GDF6 antibody can be used for detection of GDF6 by Western blot at 0.5 to 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GDF6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GDF6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Alternative Name: GDF6

Background: GDF6 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

Gene ID: 392255

NCBI Accession: NP_001001557

UniProt: Q6KF10