AKIRIN2 antibody (AA 80-130)

Catalog No. ABIN6990981

This anti-AKIRIN2 antibody is a Rabbit Polyclonal antibody detecting AKIRIN2 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for AKIRIN2 antibody (AA 80-130) (ABIN6990981)

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKIRIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-AKIRIN2 Antibody

Binding Specificity: AA 80-130

Purification: Akirin2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2. The immunogen is located within amino acids 80 - 130 of Akirin2.

Isotype: IgG

Application Details

Application Notes: Akirin2 antibody can be used for detection of Akirin2 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Akirin2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Akirin2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for AKIRIN2

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Alternative Name: Akirin2

Background: Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κ,B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κ,B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α, and IL-1β, signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Gene ID: 55122

UniProt: Q53H80

Pathways: Positive Regulation of Endopeptidase Activity