MEX3C antibody (C-Term)

Catalog No. ABIN6991001

The Rabbit Polyclonal anti-MEX3C antibody has been validated for WB and ELISA. It is suitable to detect MEX3C in samples from Human, Mouse and Rat.

Quick Overview for MEX3C antibody (C-Term) (ABIN6991001)

Target: MEX3C (Mex-3 Homolog C (C. Elegans) (MEX3C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEX3C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MEX3C Antibody

Binding Specificity: AA 540-590, C-Term

Purification: Rkhd2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rkhd2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RKHD2. The immunogen is located within amino acids 540 - 590 of Rkhd2.

Isotype: IgG

Application Details

Application Notes: Rkhd2 antibody can be used for detection of Rkhd2 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rkhd2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Rkhd2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MEX3C

Target: MEX3C (Mex-3 Homolog C (C. Elegans) (MEX3C))

Alternative Name: Rkhd2

Background: Rkhd2 Antibody: Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Gene ID: 51320

NCBI Accession: NP_057710

UniProt: Q5U5Q3