FAM120A antibody (AA 610-660)

Catalog No. ABIN6991172

The Rabbit Polyclonal anti-FAM120A antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect FAM120A in samples from Human, Mouse and Rat.

Quick Overview for FAM120A antibody (AA 610-660) (ABIN6991172)

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM120A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FAM120A Antibody

Binding Specificity: AA 610-660

Specificity: This antibody will not cross-reacti with FAM120B / PGCC1.

Purification: FAM120A Antibody is affinity chromatography purified via peptide column.

Immunogen: FAM120A antibody was raised against an 18 amino acid synthetic peptide from near the center of human FAM120A. The immunogen is located within amino acids 610 - 660 of FAM120A.

Isotype: IgG

Application Details

Application Notes: FAM120A antibody can be used for detection of FAM120A by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FAM120A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FAM120A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FAM120A

Target: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Alternative Name: FAM120A

Background: FAM120A Antibody: FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.

Gene ID: 23196

NCBI Accession: NP_055427

UniProt: Q9NZB2