Gastrin antibody (C-Term)

Catalog No. ABIN6991203

This anti-Gastrin antibody is a Rabbit Polyclonal antibody detecting Gastrin in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Gastrin antibody (C-Term) (ABIN6991203)

Target: Gastrin (GAST)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gastrin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Gastrin Antibody

Binding Specificity: C-Term

Purification: GAS Antibody is affinity chromatography purified via peptide column.

Immunogen: GAS antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human GAS. The immunogen is located within the last 50 amino acids of GAS.

Isotype: IgG

Application Details

Application Notes: GAS antibody can be used for detection of GAS by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GAS Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GAS antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Gastrin

Target: Gastrin (GAST)

Alternative Name: GAS

Background: GAS Antibody: Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.

Gene ID: 79447

NCBI Accession: NP_078792

UniProt: Q9BTK6