FRMPD2 antibody (N-Term)

Catalog No. ABIN6991212

This anti-FRMPD2 antibody is a Rabbit Polyclonal antibody detecting FRMPD2 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for FRMPD2 antibody (N-Term) (ABIN6991212)

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRMPD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FRMPD2 Antibody

Binding Specificity: AA 80-130, N-Term

Purification: FRMPD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: FRMPD2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FRMPD2. The immunogen is located within amino acids 80 - 130 of FRMPD2.

Isotype: IgG

Application Details

Application Notes: FRMPD2 antibody can be used for detection of FRMPD2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FRMPD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FRMPD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FRMPD2

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Alternative Name: FRMPD2

Background: FRMPD2 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

Gene ID: 143162

NCBI Accession: NP_001018081

UniProt: Q68DX3

Pathways: Cell-Cell Junction Organization