MAEL antibody (C-Term)

Catalog No. ABIN6991303

This Rabbit Polyclonal antibody specifically detects MAEL in ELISA, WB, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MAEL antibody (C-Term) (ABIN6991303)

Target: MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAEL antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-MAEL Antibody

Binding Specificity: AA 30-80, C-Term

Purification: Maelstrom Antibody is affinity chromatography purified via peptide column.

Immunogen: Maelstrom antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human Maelstrom. The immunogen is located within amino acids 30 - 80 of Maelstrom.

Isotype: IgG

Application Details

Application Notes: Maelstrom antibody can be used for detection of Maelstrom by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Maelstrom Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Maelstrom antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MAEL

Target: MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

Alternative Name: Maelstrom

Background: Maelstrom Antibody: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

Gene ID: 84944

UniProt: Q96JY0