FREM2 antibody (AA 1920-1970)

Catalog No. ABIN6991368

This anti-FREM2 antibody is a Rabbit Polyclonal antibody detecting FREM2 in ELISA, WB, IF and ICC. Suitable for Human and Mouse.

Quick Overview for FREM2 antibody (AA 1920-1970) (ABIN6991368)

Target: FREM2 (Fras1 Related Extracellular Matrix Protein 2 (FREM2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FREM2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-FREM2 Antibody

Binding Specificity: AA 1920-1970

Purification: FREM2 Antibody is affinity chromatography purified via peptide column.

Immunogen: FREM2 antibody was raised against a 19 amino acid synthetic peptide near the center of human FREM2. The immunogen is located within amino acids 1920 - 1970 of FREM2.

Isotype: IgG

Application Details

Application Notes: FREM2 antibody was raised against a 19 amino acid peptide near the center of human FREM2. Antibody can also be used for immunocytochemistry starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FREM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FREM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FREM2

Target: FREM2 (Fras1 Related Extracellular Matrix Protein 2 (FREM2))

Alternative Name: FREM2

Background: FREM2 Antibody: FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.

Gene ID: 341640

NCBI Accession: NP_997244

UniProt: Q5SZK8