ATP11A antibody (N-Term)

Catalog No. ABIN6991379

The Rabbit Polyclonal anti-ATP11A antibody has been validated for WB, ELISA, ICC and IF. It is suitable to detect ATP11A in samples from Human, Mouse and Rat.

Quick Overview for ATP11A antibody (N-Term) (ABIN6991379)

Target: ATP11A (ATPase, Class VI, Type 11A (ATP11A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP11A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-ATP11A Antibody

Binding Specificity: N-Term

Purification: ATP11A Antibody is affinity chromatography purified via peptide column.

Immunogen: ATP11A antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP11A. The immunogen is located within the first 50 amino acids of ATP11A.

Isotype: IgG

Application Details

Application Notes: ATP11A antibody can be used for detection of ATP11A by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATP11A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ATP11A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ATP11A

Target: ATP11A (ATPase, Class VI, Type 11A (ATP11A))

Alternative Name: ATP11A

Background: ATP11A Antibody: ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.

Gene ID: 23250

NCBI Accession: NP_115565

UniProt: P98196