NLRC3 antibody (AA 630-680)

Catalog No. ABIN6991397

The Rabbit Polyclonal anti-NLRC3 antibody is suitable to detect NLRC3 in samples from Mouse, Human and Rat. It has been validated for WB, ELISA and IF.

Quick Overview for NLRC3 antibody (AA 630-680) (ABIN6991397)

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-NLRC3 Antibody

Binding Specificity: AA 630-680

Purification: NOD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3. The immunogen is located within amino acids 630 - 680 of NOD3.

Isotype: IgG

Application Details

Application Notes: NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NOD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NOD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NLRC3

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Alternative Name: NOD3

Background: NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

Gene ID: 197358

UniProt: Q7RTR2