PIWIL2 antibody (AA 460-510)

Catalog No. ABIN6991435

This Rabbit Polyclonal antibody specifically detects PIWIL2 in ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for PIWIL2 antibody (AA 460-510) (ABIN6991435)

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIWIL2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PIWIL2 Antibody

Binding Specificity: AA 460-510

Purification: PIWI-L2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PIWI-L2 antibody was raised against a 14 amino acid synthetic peptide near the center of human PIWI-L2. The immunogen is located within amino acids 460 - 510 of PIWI-L2.

Isotype: IgG

Application Details

Application Notes: PIWI-L2 antibody can be used for detection of PIWI-L2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PIWI-L2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PIWI-L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PIWIL2

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Alternative Name: PIWI-L2

Background: PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.

Gene ID: 55124

NCBI Accession: NP_00129193

UniProt: Q8TC59

Pathways: Stem Cell Maintenance