TMEM59 antibody (N-Term)

Catalog No. ABIN6991448

The Rabbit Polyclonal anti-TMEM59 antibody is suitable to detect TMEM59 in samples from Human. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for TMEM59 antibody (N-Term) (ABIN6991448)

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TMEM59 Antibody

Binding Specificity: AA 80-130, N-Term

Purification: TMEM59 Antibody is affinity chromatography purified via peptide column.

Immunogen: TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59. The immunogen is located within amino acids 80 - 130 of TMEM59.

Isotype: IgG

Application Details

Application Notes: TMEM59 antibody can be used for detection of TMEM59 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM59 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TMEM59 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMEM59

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Alternative Name: TMEM59

Background: TMEM59 Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

Gene ID: 9528

NCBI Accession: NP_004863

UniProt: Q9BXS4