SLC39A1 antibody (N-Term)

Catalog No. ABIN6991451

Product Details anti-SLC39A1 Antibody

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least two isoforms of ZIP1 are known to exist, this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.

Purification: ZIP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1. The immunogen is located within amino acids 40 - 90 of ZIP1.

Isotype: IgG

Application Details

Application Notes: ZIP1 antibody can be used for detection of ZIP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZIP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ZIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SLC39A1

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Alternative Name: ZIP1 (SLC39A1 Products)

Synonyms: cb629 antibody, DrZIP1 antibody, sb:cb629 antibody, zgc:111852 antibody, frzip1p antibody, zip1 antibody, zirtl antibody, ZIP1 antibody, ZIRTL antibody, Zip1 antibody, Zirtl antibody, solute carrier family 39 (zinc transporter), member 1 antibody, solute carrier family 39 member 1 antibody, solute carrier family 39 member 1 L homeolog antibody, slc39a1 antibody, Slc39a1 antibody, SLC39A1 antibody, slc39a1.L antibody

Background: ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κ,B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

Molecular Weight: Predicted: 13, 36 kDa

Observed: 38 kDa

Gene ID: 27173

NCBI Accession: NP_055252

UniProt: Q9NY26

Pathways: Autophagy