Translin antibody (C-Term)

Catalog No. ABIN6991538

The Rabbit Polyclonal anti-Translin antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect Translin in samples from Human, Mouse and Rat.

Quick Overview for Translin antibody (C-Term) (ABIN6991538)

Target: Translin (TSN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Translin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Translin Antibody

Binding Specificity: C-Term

Specificity: At least two isoforms of Translin are known to exist, this antibody will detect both.

Purification: Translin Antibody is affinity chromatography purified via peptide column.

Immunogen: Translin antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human Translin. The immunogen is located within the last 50 amino acids of Translin.

Isotype: IgG

Application Details

Application Notes: Translin antibody can be used for detection of Translin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Translin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Translin antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Translin

Target: Translin (TSN)

Alternative Name: Translin

Background: Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

Gene ID: 7247

NCBI Accession: NP_004613

UniProt: Q15631