EI24 antibody (C-Term)

Catalog No. ABIN6991581

This anti-EI24 antibody is a Rabbit Polyclonal antibody detecting EI24 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for EI24 antibody (C-Term) (ABIN6991581)

Target: EI24 (Etoposide Induced 2.4 (EI24))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EI24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-EI24 Antibody

Binding Specificity: C-Term

Specificity: At least two isoforms of EI24 are known to exist, this antibody will only detect the larger isoform.

Purification: EI24 Antibody is affinity chromatography purified via peptide column.

Immunogen: EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24. The immunogen is located within the last 50 amino acids of EI24.

Isotype: IgG

Application Details

Application Notes: EI24 antibody can be used for detection of EI24 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EI24 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EI24 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for EI24

Target: EI24 (Etoposide Induced 2.4 (EI24))

Alternative Name: EI24

Background: EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.

Gene ID: 9538

NCBI Accession: NP_004870

UniProt: O14681