SPINK7/ECRG2 antibody (C-Term)

Catalog No. ABIN6991593

The Chicken Polyclonal anti-SPINK7/ECRG2 antibody (ABIN6991593) specifically detects SPINK7/ECRG2 in ELISA, WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SPINK7/ECRG2 antibody (C-Term) (ABIN6991593)

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Reactivity: Human, Mouse, Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This SPINK7/ECRG2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SPINK7/ECRG2 Antibody

Binding Specificity: C-Term

Specificity: ECRG2 antibody is predicted to not cross-react with other ECRG family members

Purification: ECRG2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.

Isotype: IgY

Application Details

Application Notes: ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ECRG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SPINK7/ECRG2

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Alternative Name: ECRG2

Background: ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

Molecular Weight: Predicted: 9 kDa

Observed: 14 kDa

Gene ID: 84651

UniProt: P58062