CD33 antibody (AA 180-230)

Catalog No. ABIN6991611

This anti-CD33 antibody is a Rabbit Polyclonal antibody detecting CD33 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for CD33 antibody (AA 180-230) (ABIN6991611)

Target: CD33

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD33 Antibody

Binding Specificity: AA 180-230

Specificity: At least three isoforms of CD33 are known to exist, this antibody will detect all three isoforms.

Purification: CD33 Antibody is affinity chromatography purified via peptide column.

Immunogen: CD33 antibody was raised against a 14 amino acid synthetic peptide near the center of human CD33. The immunogen is located within amino acids 180 - 230 of CD33.

Isotype: IgG

Application Details

Application Notes: CD33 antibody can be used for detection of CD33 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CD33 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CD33 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background: CD33 Antibody: CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimer's disease.

Gene ID: 945

NCBI Accession: NP_001763

UniProt: P20138