MLIP antibody (C-Term)

Catalog No. ABIN6991648

This Rabbit Polyclonal antibody specifically detects MLIP in WB, ELISA, IHC (p) and IF. It exhibits reactivity toward Human.

Quick Overview for MLIP antibody (C-Term) (ABIN6991648)

Target: MLIP (Muscular LMNA-Interacting Protein (MLIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-MLIP Antibody

Binding Specificity: C-Term

Specificity: At least three isoforms of MLIP are known to exist.

Purification: MLIP Antibody is affinity chromatography purified via peptide column.

Immunogen: MLIP antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human MLIP. The immunogen is located within the last 50 amino acids of MLIP.

Isotype: IgG

Application Details

Application Notes: MLIP antibody can be used for detection of MLIP by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: MLIP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: MLIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MLIP

Target: MLIP (Muscular LMNA-Interacting Protein (MLIP))

Alternative Name: MLIP

Background: MLIP Antibody: The muscle-enriched A-type lamin-interacting protein (MLIP) is ubiquitously expressed, although most predominantly in heart, skeletal and smooth muscle, and interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. Decreasing lamin A/C expression with siRNA results in the upregulation and mislocalization of MLIP, suggesting that MLIP localization to the nuclear envelope is dependent on the lamin proteins. It has been suggested that MLIP may function as a tethering protein linking LMNA to factors within the nuclear envelope of within PML bodies

Gene ID: 90523

NCBI Accession: NP_612636

UniProt: Q5VWP3