TTYH2 antibody (N-Term)

Catalog No. ABIN6991699

This Rabbit Polyclonal antibody specifically detects TTYH2 in ELISA, WB, IHC (p) and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TTYH2 antibody (N-Term) (ABIN6991699)

Target: TTYH2 (Tweety Homolog 2 (TTYH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTYH2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-TTYH2 Antibody

Binding Specificity: AA 60-110, N-Term

Specificity: At least four isoforms of TTYH2 are known to exist, this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.

Purification: TTYH2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2. The immunogen is located within amino acids 60 - 110 of TTYH2.

Isotype: IgG

Application Details

Application Notes: TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TTYH2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TTYH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TTYH2

Target: TTYH2 (Tweety Homolog 2 (TTYH2))

Alternative Name: TTYH2

Background: TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

Gene ID: 94015

NCBI Accession: NP_116035

UniProt: Q9BSA4