PHOX2B antibody (AA 130-180)

Catalog No. ABIN6991707

This anti-PHOX2B antibody is a Rabbit Polyclonal antibody detecting PHOX2B in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for PHOX2B antibody (AA 130-180) (ABIN6991707)

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PHOX2B Antibody

Binding Specificity: AA 130-180

Specificity: PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.

Purification: PHOX2B Antibody is affinity chromatography purified via peptide column.

Immunogen: PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B. The immunogen is located within amino acids 130 - 180 of PHOX2B.

Isotype: IgG

Application Details

Application Notes: PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PHOX2B Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PHOX2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PHOX2B

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Alternative Name: PHOX2B

Background: PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

Gene ID: 8929

NCBI Accession: NP_003915

UniProt: Q99453