EPM2A antibody (C-Term)

Catalog No. ABIN6991748

The Rabbit Polyclonal anti-EPM2A antibody is suitable to detect EPM2A in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for EPM2A antibody (C-Term) (ABIN6991748)

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPM2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-EPM2A Antibody

Binding Specificity: AA 190-240, C-Term

Specificity: At least four isoforms of EPM2A are known to exist, this antibody will detect all but the shortest isoform.

Purification: EPM2A Antibody is affinity chromatography purified via peptide column.

Immunogen: EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A. The immunogen is located within amino acids 190 - 240 of EPM2A.

Isotype: IgG

Application Details

Application Notes: EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EPM2A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EPM2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for EPM2A

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Alternative Name: EPM2A

Background: EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.

Molecular Weight: 36 kDa

Gene ID: 7957

NCBI Accession: NP_005661

UniProt: O95278

Pathways: Cellular Glucan Metabolic Process