AGR2 antibody (N-Term)

Catalog No. ABIN6991826

The Rabbit Polyclonal anti-AGR2 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect AGR2 in samples from Human and Mouse.

Quick Overview for AGR2 antibody (N-Term) (ABIN6991826)

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AGR2 Antibody

Binding Specificity: N-Term

Specificity: Two isoforms of AGR2 exists as a result of alternative splicing event.

Purification: AGR2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal AGR2 antibody was raised against a 17 amino acid peptide near the amino terminus of human AGR2. The immunogen is located within the first 50 amino acids of AGR2.

Isotype: IgG

Application Details

Application Notes: AGR2 antibody can be used for detection of AGR2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: AGR2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: AGR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for AGR2

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Alternative Name: AGR2

Background: AGR2 Antibody: AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).

Molecular Weight: 19 kDa

Gene ID: 10551

NCBI Accession: NP_006399

UniProt: O95994