TRIM33 antibody (AA 580-630)

Catalog No. ABIN6991872

This anti-TRIM33 antibody is a Rabbit Polyclonal antibody detecting TRIM33 in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for TRIM33 antibody (AA 580-630) (ABIN6991872)

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TRIM33 Antibody

Binding Specificity: AA 580-630

Specificity: TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.

Purification: TRIM33 Antibody is affinity chromatography purified via peptide column.

Immunogen: TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33. The immunogen is located within amino acids 580 - 630 of TRIM33.

Isotype: IgG

Application Details

Application Notes: TRIM33 antibody can be used for detection of TRIM33 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIM33 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TRIM33 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TRIM33

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Alternative Name: TRIM33

Background: TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).

Molecular Weight: Predicted: 70, 124 kDa

Observed: 70 kDa

Gene ID: 51592

NCBI Accession: NP_056990

UniProt: Q9UPN9