BimEL antibody (N-Term)

Catalog No. ABIN6991882

This Rabbit Polyclonal antibody specifically detects BimEL in WB, ELISA, ICC and IF. It exhibits reactivity toward Rat, Human and Mouse.

Quick Overview for BimEL antibody (N-Term) (ABIN6991882)

Target: BimEL

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BimEL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-BimEL Antibody

Binding Specificity: AA 20-70, N-Term

Specificity: Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist, this antibody only detects the Bim EL isoform.

Purification: Bim EL Antibody is affinity chromatography purified via peptide column.

Immunogen: Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim. The immunogen is located within amino acids 20 - 70 of Bim EL.

Isotype: IgG

Application Details

Application Notes: Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bim EL Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for BimEL

Target: BimEL

Alternative Name: Bim EL

Background: Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).

Molecular Weight: Predicted: 22 kDa

Observed: 24 kDa

Gene ID: 10018

NCBI Accession: NP_619527

UniProt: O43521