KHDC1 antibody (N-Term)

Catalog No. ABIN6991883

The Rabbit Polyclonal anti-KHDC1 antibody has been validated for ELISA, WB and IHC (p). It is suitable to detect KHDC1 in samples from Human, Mouse and Rat.

Quick Overview for KHDC1 antibody (N-Term) (ABIN6991883)

Target: KHDC1 (KH Homology Domain Containing 1 (KHDC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHDC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KHDC1 Antibody

Binding Specificity: AA 30-80, N-Term

Specificity: KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist, this antibody will only detect the longest isoform.

Purification: KHDC1 Antibody is affinity chromatography purified via peptide column.

Immunogen: KHDC1 antibody was raised against a 15 amino acid peptide near the amino terminus of human KHDC1. The immunogen is located within amino acids 30 - 80 of KHDC1.

Isotype: IgG

Application Details

Application Notes: KHDC1 antibody can be used for detection of KHDC1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KHDC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KHDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for KHDC1

Target: KHDC1 (KH Homology Domain Containing 1 (KHDC1))

Alternative Name: KHDC1

Background: KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1). KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3). KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4).

Molecular Weight: Predicted: 18 kDa

Observed: 26 kDa

Gene ID: 80759

NCBI Accession: NP_085045

UniProt: Q4VXA5