Arylsulfatase B antibody (C-Term)

Catalog No. ABIN6991898

The Rabbit Polyclonal anti-Arylsulfatase B antibody has been validated for WB, ELISA, IHC (p) and IF. It is suitable to detect Arylsulfatase B in samples from Human, Mouse and Rat.

Quick Overview for Arylsulfatase B antibody (C-Term) (ABIN6991898)

Target: Arylsulfatase B (ARSB)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Arylsulfatase B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Arylsulfatase B Antibody

Binding Specificity: AA 460-510, C-Term

Specificity: ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist, this antibody only recognizes the longest isoform.

Purification: ARSB Antibody is affinity chromatography purified via peptide column.

Immunogen: ARSB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ARSB. The immunogen is located within amino acids 460 - 510 of ARSB .

Isotype: IgG

Application Details

Application Notes: ARSB antibody can be used for detection of ARSB by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ARSB Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ARSB antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Arylsulfatase B

Target: Arylsulfatase B (ARSB)

Alternative Name: ARSB

Background: Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1). ARSB localizes to the lysozyme as well as to the extracellular matrix (2). Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4).

Molecular Weight: Predicted: 59 kDa

Observed: 57kDa

Gene ID: 411

NCBI Accession: NP_000037

UniProt: P15848

Pathways: Glycosaminoglycan Metabolic Process