CXCR3 antibody (C-Term)

Catalog No. ABIN6991955

The Rabbit Polyclonal anti-CXCR3 antibody has been validated for WB, ELISA, ICC and IF. It is suitable to detect CXCR3 in samples from Human, Mouse and Rat.

Quick Overview for CXCR3 antibody (C-Term) (ABIN6991955)

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-CXCR3 Antibody

Binding Specificity: C-Term

Specificity: CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist, this antibody will detect both isoforms.

Purification: CXCR3 antibody is affinity chromatography purified via peptide column.

Immunogen: CXCR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human CXCR3 . The immunogen is located within the last 50 amino acids of CXCR3.

Isotype: IgG

Application Details

Application Notes: CXCR3 antibody can be used for detection of CXCR3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CXCR3 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CXCR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CXCR3

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Alternative Name: CXCR3

Background: The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2). Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3).

Molecular Weight: Predicted: 46 kDa

Observed: 43 kDa

Gene ID: 2833

NCBI Accession: NP_001136269

UniProt: P49682