IFIT1 antibody (C-Term)

Catalog No. ABIN6991993

This Rabbit Polyclonal antibody specifically detects IFIT1 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IFIT1 antibody (C-Term) (ABIN6991993)

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IFIT1 Antibody

Binding Specificity: AA 290-340, C-Term

Specificity: IFIT1 antibody is human, mouse and rat reactive. At least three isoforms of IFIT1 are known to exist. This antibody is predicted to not cross-react with other members of the IFIT protein family.

Purification: IFIT1 antibody is affinity chromatography purified via peptide column.

Immunogen: IFIT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT1. The immunogen is located within amino acids 290 - 340 of IFIT1.

Isotype: IgG

Application Details

Application Notes: IFIT1 antibody can be used for detection of IFIT1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IFIT1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IFIT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IFIT1

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Alternative Name: IFIT1

Background: The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2). These proteins have been suggested to induce anti-viral cellular activities in response to infection (2). Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments (3).

Molecular Weight: Predicted: 53 kDa

Observed: 53 kDa

Gene ID: 3434

NCBI Accession: NP_001539

UniProt: P09914

Pathways: Hepatitis C