Chromosome 5 Open Reading Frame 20 (C5ORF20) (N-Term) antibody

Catalog No. ABIN6991996

This Rabbit Polyclonal antibody specifically detects in WB, ELISA, IHC (p) and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Chromosome 5 Open Reading Frame 20 (C5ORF20) (N-Term) antibody (ABIN6991996)

Target: Chromosome 5 Open Reading Frame 20 (C5ORF20)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details

Binding Specificity: N-Term

Specificity: DCNP1 antibody is human, mouse and rat reactive.

Purification: DCNP1 antibody is affinity chromatography purified via peptide column.

Immunogen: DCNP1 antibody was raised against an 18 amino acid peptide near the amino terminus of human DCNP1. The immunogen is located within the first 50 amino acids of DCNP1.

Isotype: IgG

Application Details

Application Notes: DCNP1 antibody can be used for detection of DCNP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DCNP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DCNP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details

Target: Chromosome 5 Open Reading Frame 20 (C5ORF20)

Alternative Name: DCNP1

Background: The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1). It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3). DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4).

Molecular Weight: Predicted: 27 kDa

Observed: 24 kDa

Gene ID: 140947

NCBI Accession: NP_570900

UniProt: Q8TF63