GABARAPL2 antibody (C-Term)

Catalog No. ABIN6992033

The Rabbit Polyclonal anti-GABARAPL2 antibody has been validated for ELISA, WB, IF and IHC (p). It is suitable to detect GABARAPL2 in samples from Human, Mouse and Rat.

Quick Overview for GABARAPL2 antibody (C-Term) (ABIN6992033)

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABARAPL2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GABARAPL2 Antibody

Binding Specificity: C-Term

Specificity: GABARAPL2 antibody is human, mouse and rat reactive. Multiple isoforms of GABARAPL2 are known to exist.

Purification: GABARAPL2 antibody is affinity chromatography purified via peptide column.

Immunogen: GABARAPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human GABARAPL2. The immunogen is located within the last 50 amino acids of GABARAPL2.

Isotype: IgG

Application Details

Application Notes: GABARAPL2 antibody can be used for detection of GABARAPL2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GABARAPL2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GABARAPL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GABARAPL2

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Alternative Name: GABARAPL2

Background: Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system (1). It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2). GABARAPL2 (GABAA receptor-associated protein-like 2), also known as GATE16, was initially identified as a membrane transport modulator and is a mammalian ortholog to the autophagy protein ATG8 (3,4). It is thought that GABARAPL2 and other members of the ATG8 family act as scaffolds for assembly of the Unc-51 like kinase (ULK) complex in the formation of autophagosomes (5).

Molecular Weight: Predicted: 13 kDa

Observed: 13 kDa

Gene ID: 11345

NCBI Accession: NP_009216

UniProt: P60520

Pathways: Autophagy