HDAC1 antibody (C-Term)

Catalog No. ABIN6992034

This anti-HDAC1 antibody is a Rabbit Polyclonal antibody detecting HDAC1 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for HDAC1 antibody (C-Term) (ABIN6992034)

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HDAC1 Antibody

Binding Specificity: C-Term

Specificity: HDAC1 antibody is human, mouse and rat reactive. HDAC1 antibody is predicted to not cross-react with other members of the HDAC family.

Purification: HDAC1 antibody is affinity chromatography purified via peptide column.

Immunogen: HDAC1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human HDAC1. The immunogen is located within the last 50 amino acids of HDAC1.

Isotype: IgG

Application Details

Application Notes: HDAC1 antibody can be used for detection of HDAC1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: HDAC1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: HDAC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: HDAC1

Background: The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class I of the HDAC family comprises four members, HDAC1, 2, 3, and 8, each of which contains a deacetylase domain and exhibits a different, individual substrate specificity and function in vivo (1). HDAC1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (1,2). HDAC1 gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (3,4).

Molecular Weight: Predicted: 53 kDa

Observed: 54 kDa

Gene ID: 3065

NCBI Accession: NP_004955

UniProt: Q13547

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis