Ectodysplasin A antibody (AA 130-180)

Catalog No. ABIN6992088

This anti-Ectodysplasin A antibody is a Rabbit Polyclonal antibody detecting Ectodysplasin A in WB, ELISA, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for Ectodysplasin A antibody (AA 130-180) (ABIN6992088)

Target: Ectodysplasin A (EDA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ectodysplasin A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Ectodysplasin A Antibody

Binding Specificity: AA 130-180

Specificity: EDA1 antibody is human, mouse and rat reactive. Multiple isoforms of EDA1 are known to exist.

Purification: EDA1 antibody is affinity chromatography purified via peptide column.

Immunogen: EDA1 antibody was raised against an 19 amino acid peptide near the center of human EDA1. The immunogen is located within amino acids 130 - 180 of EDA1.

Isotype: IgG

Application Details

Application Notes: EDA1 antibody can be used for detection of EDA1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EDA1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EDA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Ectodysplasin A

Target: Ectodysplasin A (EDA)

Alternative Name: EDA1

Background: Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1). It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3). EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5).

Molecular Weight: Predicted: 16, 43 kDa

Observed: 39 kDa

Gene ID: 1896

NCBI Accession: NP_001390

UniProt: Q92838

Pathways: Tube Formation