GLIS2 antibody (AA 260-310)

Catalog No. ABIN6992104

This Rabbit Polyclonal antibody specifically detects GLIS2 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GLIS2 antibody (AA 260-310) (ABIN6992104)

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLIS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GLIS2 Antibody

Binding Specificity: AA 260-310

Specificity: GLIS2 antibody is human, mouse and rat reactive.

Purification: GLIS2 antibody is affinity chromatography purified via peptide column.

Immunogen: GLIS2 antibody was raised against an 18 amino acid peptide near the center of human GLIS2. The immunogen is located within amino acids 260 - 310 of GLIS2.

Isotype: IgG

Application Details

Application Notes: GLIS2 antibody can be used for detection of GLIS2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GLIS2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GLIS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GLIS2

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Alternative Name: GLIS2

Background: GLIS2, also known as neuronal Krueppel-like, is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family (1). GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation (1,2). GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Mutations of GLIS2 have been suggested to be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis (3,4).

Molecular Weight: Predicted: 58 kDa

Observed: 60 kDa

Gene ID: 84662

NCBI Accession: NP_115964

UniProt: Q9BZE0