ADRM1 antibody (AA 210-260)

Catalog No. ABIN6992113

This Rabbit Polyclonal antibody specifically detects ADRM1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ADRM1 antibody (AA 210-260) (ABIN6992113)

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ADRM1 Antibody

Binding Specificity: AA 210-260

Specificity: ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist, this antibody will detect both isoforms.

Purification: ADRM1 antibody is affinity chromatography purified via peptide column.

Immunogen: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1. The immunogen is located within amino acids 210 - 260 of ADRM1.

Isotype: IgG

Application Details

Application Notes: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADRM1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ADRM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ADRM1

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Alternative Name: ADRM1

Background: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).

Molecular Weight: Predicted: 45 kDa

Observed: 48 kDa

Gene ID: 11047

NCBI Accession: NP_783163

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity