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DIS3L2 antibody (C-Term)

The Rabbit Polyclonal anti-DIS3L2 antibody has been validated for WB and ELISA. It is suitable to detect DIS3L2 in samples from Human, Mouse and Rat.
Catalog No. ABIN6992168

Quick Overview for DIS3L2 antibody (C-Term) (ABIN6992168)

Target

See all DIS3L2 Antibodies
DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This DIS3L2 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA
  • Binding Specificity

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    AA 720-770, C-Term

    Specificity

    DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

    Purification

    DIS3L2 antibody is affinity chromatography purified via peptide column.

    Immunogen

    DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.

    Isotype

    IgG
  • Application Notes

    DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

    Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

    Alternative Name

    DIS3L2

    Background

    The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

    Molecular Weight

    Predicted: 97 kDa

    Observed: 94 kDa

    Gene ID

    129563

    NCBI Accession

    NP_689596

    UniProt

    Q8IYB7

    Pathways

    Stem Cell Maintenance
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