CRELD2 antibody

Catalog No. ABIN7236677

The Rabbit Polyclonal anti-CRELD2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect CRELD2 in samples from Human.

Quick Overview for CRELD2 antibody (ABIN7236677)

Target: CRELD2 (Cysteine-Rich with EGF-Like Domains 2 (CRELD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRELD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CRELD2 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human CRELD2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CRELD2

Target: CRELD2 (Cysteine-Rich with EGF-Like Domains 2 (CRELD2))

Alternative Name: CRELD2

Background: The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR4, possibly regulating its transport. Human CRELD2 shares 69 % amino acid identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

Molecular Weight: 38 kDa

UniProt: Q6UXH1