HSP40-4 antibody

Catalog No. ABIN7237214

The Rabbit Polyclonal anti-HSP40-4 antibody is suitable to detect HSP40-4 in samples from Human, Mouse and Rat. It has been validated for IHC, ELISA and WB.

Quick Overview for HSP40-4 antibody (ABIN7237214)

Target: HSP40-4

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Product Details

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human DNAJA1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: HSP40-4

Background: DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Molecular Weight: 45 kDa

UniProt: P31689