SRGAP3 antibody

Catalog No. ABIN7237712

This anti-SRGAP3 antibody is a Rabbit Polyclonal antibody detecting SRGAP3 in ELISA and IHC. Suitable for Human and Mouse.

Quick Overview for SRGAP3 antibody (ABIN7237712)

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-SRGAP3 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human SRGAP3

Isotype: IgG

Application Details

Application Notes: IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SRGAP3

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Alternative Name: SRGAP3

Background: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

UniProt: O43295