CLDN8 antibody

Catalog No. ABIN7238087

The Rabbit Polyclonal anti-CLDN8 antibody has been validated for ELISA and IHC. It is suitable to detect CLDN8 in samples from Human.

Quick Overview for CLDN8 antibody (ABIN7238087)

Target: CLDN8 (Claudin 8 (CLDN8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLDN8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CLDN8 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human CLDN8

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CLDN8

Target: CLDN8 (Claudin 8 (CLDN8))

Alternative Name: Claudin 8

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

NCBI Accession: NP_955360

UniProt: P56748

Pathways: Hepatitis C