SLC17A1
Reactivity: Human
Host: Rabbit
Polyclonal
Alexa Fluor 555
Application Notes
WB 1:500-1:2000
Restrictions
For Research Use only
Format
Liquid
Concentration
0.6 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target
SLC17A1
(Solute Carrier Family 17 Member 1 (SLC17A1))
Alternative Name
SLC17A1
Background
NPT1, also called sodium-dependent phosphate transport protein, belongs to the organic anion transporter family, SLC17A. It is mainly expressed in the kidney transporting small organic anions such as PAH (para-aminohippurate), but it is also found in the liver and brain. NTP1 localizes to the apical membrane of renal proximal tubular cells and functions as a voltage driven organic anion/Cl-exchanger. It also plays a role in maintaining phosphate homeostasis. The expression of NPT1 is transcriptionally regulated by HNF-1 and HNF-3. Indomethacin and salicylate inhibit NPT1-mediated PAH transport.