CEND1 antibody

Catalog No. ABIN7248425

The Rabbit Polyclonal anti-CEND1 antibody has been validated for ELISA, WB and IHC. It is suitable to detect CEND1 in samples from Human, Mouse and Rat.

Quick Overview for CEND1 antibody (ABIN7248425)

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEND1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CEND1 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human CEND1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CEND1

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Alternative Name: CEND1

Background: BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 15 kDa

UniProt: Q8N111