ATIC antibody

Catalog No. ABIN7005053

This Rabbit Polyclonal antibody specifically detects ATIC in WB and ELISA. It exhibits reactivity toward Human, Mouse and Ratand has been mentioned in 1 publication.

Quick Overview for ATIC antibody (ABIN7005053)

Target: ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATIC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ATIC Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Fusion protein of human ATIC

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:2000-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ATIC antibody (ABIN7005053)

Dolinar, Miš, Šopar, Šutar, Božič, Kolar, Hropot, Garcia-Roves, Chibalin, Pirkmajer: "Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR-Induced AMPK Activation and Glucose Uptake in L6 Myotubes." in: BioFactors (Oxford, England), Vol. 51, Issue 4, pp. e70037, (2025) (PubMed).

Target Details for ATIC

Target: ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))

Alternative Name: ATIC

Background: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

Molecular Weight: 65 kDa

UniProt: P31939